Jennifer Aniston will always be Rachel Green, Jim Parsons will always be Sheldon, and Daniel Radcliffe will always be Harry, try as he might to be Weird Al. 

Robert Pattinson will only ever be the sparkly vampire.

Juliette Lewis will alwayssssss be The Other Sister for me.

That's John Krasinski for me. God bless him for trying to be Jack Ryan, but he is, and always will be, Jim Halpert. I watched an ep of Jack Ryan and was like, when did Jim join the CIA??? (Or whatever org it was.) I couldn't get over it.

I will always only see Max Greenfield as Schmidt. Even when he popped up in a rewatch of Ugly Betty, I was like, “That’s Schmidt.” 

The other day I was watching the new season of Barry, and I totally forgot that D'Arcy Carden has a small role in it. As much as I love her and think she is incredibly talented...I just see her as Janet from The Good Place. There are a few other actors/actresses that, no matter what role they're in, you always see them as their most popular character, thereby ruining the illusion that they are someone else. Steven Yeun is another person who I always still think of him as Glenn from The Walking Dead.

THEN you have actors like Brad and Leo, (and now Depp, to be honest!) who no matter what movie they're in, I just see them themselves. I feel bad because it's almost like their personality is so big it overshadows any work they actually do.

Actors who will forever be their most popular character